Difference between Live and Killed vaccine
| Features | Live Vaccine | Killed Vaccine |
| Dose administered | Single dose | Multiple dose |
| Stability | Less stable | More stable |
| Immunity induction | Both Antibody mediated and Cell mediated Immunity | Mainly Antibody mediated immunity |
| Cell mediated Immunity | Good | Poor |
| Duration of Immunity | Many years | less |
| Antibody response | IgG | IgG, IgA |
| Need of Adjuvant | No | Yes |
| Reversion of Virulence | Possible | Not Possible |
| Production | Selection of avirulent organism by growing virulent organism in adverse culture conditionSelection of avirulent organism by prolong passage of avirulent pathogen through different hostAttenuation by genetic engineering | Directly virulent pathogen is killed or inactivated by chemicals (formaldehyde or Alkylating agents) , gamma rays or heat |
| Examples | Sabin’s Polio vaccine, Measles vaccine, BCG | Anthrax vaccine, Cholera Vaccine, Purtusis vaccine |