live and killed vaccine Archives - Online Biology Notes A Complete notes for Students Fri, 06 Dec 2019 14:45:23 +0000 en-US hourly 1 Difference between Live and Killed vaccine https://www.onlinebiologynotes.com/difference-between-live-and-killed-vaccine/ Fri, 06 Dec 2019 14:45:19 +0000 https://www.onlinebiologynotes.com/?p=2277 Difference between Live and Killed vaccine Features Live Vaccine Killed Vaccine Dose administered Single dose Multiple dose Stability Less stable More stable Immunity induction Both [...]

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Features Live Vaccine Killed Vaccine
Dose administered Single dose Multiple dose
Stability Less stable More stable
Immunity induction Both Antibody mediated and Cell mediated Immunity Mainly Antibody mediated immunity
Cell mediated Immunity Good Poor
Duration of Immunity Many years less
Antibody response IgG IgG, IgA
Need of Adjuvant No Yes
Reversion of Virulence Possible Not Possible
Production Selection of avirulent organism by growing virulent organism in adverse culture conditionSelection of avirulent organism by prolong passage of avirulent pathogen through different hostAttenuation by genetic engineering   Directly virulent pathogen is killed or inactivated by chemicals (formaldehyde or Alkylating agents) , gamma rays or heat
Examples Sabin’s Polio vaccine, Measles vaccine, BCG Anthrax vaccine, Cholera Vaccine, Purtusis vaccine

Difference between Live and Killed vaccine

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